Professor in Animal and Human Physiology and Neurobiology at the Department of Biology at the National and Kapodistrian University of Athens in Greece

Professor, B.Sc., Ph.D.

Education
University of Patras, Dept. of Biology, B.Sc. in Biology (1986)
University of Patras, Dept. of Biology, Ph.D. in Neurobiology (1991)

Academic Roles
2013-present: Professor, University of Athens, Department of Biology
2007-2013: Associate Professor, University of Athens, Department of Biology
2001-2007: Assistant Professor, University of Athens, Department of Biology
1996-present: Adjunct Assistant Professor, Mount Sinai School of Medicine, Dept. of Psychiatry.
1994-1996: Res. Assistant Professor, Mount Sinai Sch. of Med., Dept. of Psychiatry.
1991-1994: Visiting Scientist, Mount Sinai School of Medicine, Dept. of Psychiatry.

Administrative Duties
Member of the general assembly of the Department of Biology at the the National and Kapodistrian University of Athens
Memebr of the Study Program Committee at the Department of Biology of the National and Kapodistrian University of Athens
President of the Hellenic Society for Neurosciences
Secretary of the Hellenic Society for Neurosciences
President of the Hellenic Society for Biological Sciences 
Vice President of the Hellenic Society for Biological Sciences
Member of the Scientific Committee of the Internationall Conference AD/PD
President and member of the scientific conference organizing committees

Research Interests
Molecular and Cellular biology of Alzheimer’s Disease.
Molecular and Cellular biology of British and Danish dementias

Selected Publications

1. Paschou M, Liaropoulou D, Kalaitzaki V, Efthimiopoulos S, Papazafiri P. (2023). Knockdown of Amyloid Precursor Protein Increases Ion Channel Expression and Alters Ca2+ Signaling Pathways. Int J Mol Sci. 24;24(3):2302. 
2. Chatzistavraki M, Papazafiri P, Efthimiopoulos S. (2020). Amyloid precursor protein regulates depolarization-induced calcium-mediated synaptic signaling in brain slices. J Alzheimers Dis. 76(3):1121-1133.
3. Gourgouli K, Gourgouli I, Tsaousis G, Spai S, Niskopoulou M, Efthimiopoulos S, Lamnissou K. (2020). Investigation of genetic base in the treatment of age-related macular degeneration. Int Ophthalmol. 40(4):985-997.
4. Thysiadis S, Katsamakas S, Mpousis S, Avramidis N, Efthimiopoulos S, Sarli V. (2018). Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease. Bioorg Chem. 80:230-244.
5. Matis Ι, Delivoria DC, Mavroidi B, Papaevgeniou N, Panoutsou S, Bellou S, Papavasileiou KD, Linardaki Z, Stavropoulou AV, Vekrellis K, Boukos N, Kolisis FN, Gonos ES, Margarity M, Papadopoulos MG, Efthimiopoulos S, Pelecanou M, Chondrogianni N, Skretas G (2017). An integrated and generalizable bacterial discovery platform for chemical 1 rescuers of disease-associated protein misfolding. Nature Biomedical Engineering1(10):838-852. 
6. Mavroeidi P, Mavrofrydi O, Pappa E, Panopoulou M, Papazafiri P, Ηaralambous S, Efthimiopoulos S. (2017). Oxygen and glucose deprivation alter synaptic distribution of tau protein. Journal of Alzheimer's Disease 60(2):593-604
7. Stavropoulou AV, Mavrofrydi O, Saftig P, Efthimiopoulos S. (2017). Serum starvation induces BACE1 processing and secretion. Curr Alzheimer Res 14(4):453-459. 
8. Thysiadis S, Mpousis S, Avramidis N, Katsamakas S, Balomenos A, Remelli R, Efthimiopoulos S, Sarli V. (2016). Discovery of novel phenoxazinone derivatives as DKK1/LRP6 interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships. Bioorg Med Chem. 2016 24(5):1014-22 
9. Kyratzi E, Liakos A, Papadogiannaki G, Efthimiopoulos S. (2015). Structural and Regulatory Elements of the Interaction between Amyloid-β Protein Precursor and Homer3.J Alzheimers Dis. 2015 45(1):147-57. 
10. Kyratzi E. & Efthimiopoulos S. (2014) Calcium regulates the interaction of Amyloid Precursor Protein with Homer3 protein. Neurobiology of Aging 35: 2053-2063. 
11. Tsachaki M., Slavi N., Fotinopoulou A., Zarkou V., Ghiso J., Efthimiopoulos S., (2013). BRI2 interacts with BACE1 and reduces its cellular levels by reducing the levels of BACE1 mRNA and inducing its degradation through the lysosomal pathway.  Current Alzheimer’s Disease Research 10(5):532-541. 
12. Chatzistavraki Μ., Kyratzi Ε., Fotinopoulou Α., Papazafiri Π., Efthimiopoulos S., (2013) Downregulation of APP enhances both calcium content of endoplasmic reticulum and acidic stores and the dynamics of store operated calcium channel activity. Journal of Alzheimer’s Disease 34(2):407-15. 
13. Tsachaki M, Serlidaki D, Fetani A, Zarkou V, Rozani I, Ghiso J, Efthimiopoulos S. (2011).Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10. Glycobiology, 21(10):1382-8.